Au nanoshell-coated superparamagnetic Fe3O4–silica composite nanoparticles with surface-modification of an activatable cell-penetrating peptide for tumor-targeted multimode bioimaging and photothermal therapy. Issue 88 (8th September 2016)

• Record Type: Journal Article
• Authors: Jiang, Yunfang; Zhang, Qianyu; Liu, Xinghua; Chen, Yifu; Wang, Li; Fu, Jingwei; Duan, Hongquan; Wang, Yinsong; Yang, Xiaoying
• Is Part Of: RSC advances. Volume 6:Issue 88(2016)
• Page Start: 85587
• Page End: 85594
• Publication Date: 2016-09-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra07708k
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The superparamagnetic Fe3 O4 –silica composite nanoparticles coated with Au nanoshells were prepared and subsequently surface-modified with PEG conjugated ACPP for realizing the tumor site-specific multimode bioimaging and photothermal therapy. Abstract : High-resolution imaging of molecules intrinsically involved in malignancy and metastasis would be of great value for clinical detection and staging of tumors. Based on the selective cell-penetrating ability in the tumor sites of the activatable cell-penetrating peptide (ACPP), the superparamagnetic Fe3 O4 –silica composite nanoparticles (SSCNs) coated with Au nanoshells (AuNSs) were prepared and subsequently surface-modified with polyethylene glycol (PEG) conjugated an ACPP to form SSCNs@AuNSs-PEG-ACPP nanoparticles for realizing tumor site-specific multimode bioimaging and photothermal therapy. SSCNs@AuNSs-PEG-ACPP nanoparticles showed high photothermal efficiency, X-ray attenuation property and T 2 relaxation rate, which were confirmed by a series of characterizations in vitro and in vivo . The enhanced accumulation of SSCNs@AuNSs-PEG-ACPP nanoparticles in the tumor was investigated by the in vivo X-ray computed tomography (CT) imaging and magnetic resonance (MR) imaging. SSCNs@AuNSs-PEG-ACPP nanoparticles will be likely to realize simultaneous CT/MR bioimaging and photothermal therapy on the tumor by the combination of superparamagnetization, X-ray attenuation property, near-infrared (NIR) absorption and tumor-selected accumulation.