Synthesis and dark toxicity of 5-(4-carboxyphenyl)-10, 15, 20-tris(phenyl)-porphyrinato chlorido gallium(III) when conjugated to δ-aminolevulinic acid. Issue 20 (17th October 2016)

• Record Type: Journal Article
• Authors: Managa, Muthumuni; Mkhize, Scebi; Britton, Jonathan; Prinsloo, Earl; Nyokong, Tebello
• Is Part Of: Journal of coordination chemistry. Volume 69:Issue 20(2016)
• Page Start: 3035
• Page End: 3042
• Publication Date: 2016-10-17
• Subjects: Dark toxicity -- δ-aminolevulinic acid -- photophysical studies -- cancer cells -- porphyrin; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2016.1223292
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: 5-(4-Carboxyphenyl)-10, 15, 20-tris(phenyl)-porphyrinato chlorido gallium(III) (2 ) was synthesized and then linked to ethyl ester δ-aminolevulinic acid to form3 . There was no shift in Soret band following conjugation. The fluorescence and singlet oxygen generating behavior of the porphyrins were also investigated. The highest singlet oxygen quantum yield (ΦΔ ) obtained was that of3 . Complexes2 and3 as well as metal free 5-(4-carboxyphenyl)-10, 15, 20-tris(phenyl)-porphyrinato showed no dark toxicity on MCF-7 breast cancer cells. Abstract :