Dinuclear cadmium indomethacin and Lawsone complexes: synthesis, crystal structures, antiproliferative and biological evaluations. Issue 20 (17th October 2016)

• Record Type: Journal Article
• Authors: Tabrizi, Leila; Golbang, Reza; Sadeghi, Hamid; Chiniforoshan, Hossein; Mcardle, Patrick; Notash, Behrouz
• Is Part Of: Journal of coordination chemistry. Volume 69:Issue 20(2016)
• Page Start: 3021
• Page End: 3034
• Publication Date: 2016-10-17
• Subjects: Cadmium(II) complex -- indomethacin -- Lawsone -- DNA binding -- BSA binding -- cytotoxicity; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2016.1223845
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: The synthesis and structural characterizations of Cd(II) indomethacin (Indo) and Lawsone (Law) complexes, K2 [Cd2 (Indo)4 (SCN)2 ], 1 and [Cd2 (Law)4 (phen)2 ]·4CH3 OH, 2 (SCN = thiocyanate, phen = 1, 10-phenanthroline), have been studied. The complexes are dimeric, structurally characterized by spectral (IR, TOF-Mass) and X-ray crystallography. The interaction of indomethacin and Lawsone ligands, 1 and2 with calf thymus DNA and bovine serum albumin were investigated using UV–visible and fluorescence spectrophotometric methods. The in vitro cytotoxicity of1 and2 was examined against promyelocytic leukemia (HL-60), colon (HCT-8), brain (SF-295), and melanoma (MDA-MB-435) cancer cell lines. Moreover, the antimicrobial activity of1 and2 against different strains of pathogenic bacteria were tested. Abstract :