Recent developments in the chemistry of bicyclic 6-6 systems: Chemistry of pyrido[1, 2-c]pyrimidines. Issue 18 (16th September 2016)

• Record Type: Journal Article
• Authors: Elattar, Khaled M.; Rabie, Ramy; Hammouda, Mohamed M.
• Is Part Of: Synthetic communications. Volume 46:Issue 18(2016)
• Page Start: 1477
• Page End: 1498
• Publication Date: 2016-09-16
• Subjects: Chemical structure studies -- pyrido[1, 2-c]pyrimidines -- reactions and synthetic applications -- spectroscopy; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2016.1211702
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: The present review provides a study on the structural features, reactions, and synthetic methodologies of pyrido[1, 2- c ]pyrimidines. The maximum deviation from the mean plane of the pyridopyrimidine skeleton of 4-(pyridin-2-yl)-1 H -pyrido[1, 2- c ]pyrimidine-1, 3(2 H )-dione indicated a reasonably planar system. The aim of this review is to give an overview of the diverse methodologies that have been reported on the chemistry of pyrido[1, 2- c ]pyrimidines. The different synthetic routes have been grouped according to the way the pyrido[1, 2- c ]pyrimidine moiety has been created. Thus, pyrido[1, 2- c ]pyrimidine compounds were obtained by the formation of one bondα to the bridgehead nitrogen atom [6+0(β )] and formation of two bonds from ([3+3], [4+2], and [5+1]) atom fragments. The mechanistic pathways of the reactions are discussed. GRAPHICAL ABSTRACT: