Effect of low-intensity pure tone auditory stimulation on patients with rapid eye movement sleep behavior disorder. (1st September 2016)

• Record Type: Journal Article
• Authors: Zhang, Lin; Xu, Yixin; Zhuang, Jianhua; Peng, Hua; Wu, Huijuan; Zhao, Zhengqing; He, Bin; Zhao, Zhongxin
• Is Part Of: Neurological research. Volume 38:Number 9(2016)
• Page Start: 792
• Page End: 798
• Publication Date: 2016-09-01
• Subjects: Auditory stimulation -- Rapid eye movement sleep behavior disorders -- Eye movement -- Sleep efficiency -- Sleep architecture; Neurology -- Periodicals; Neurosciences -- Periodicals; 616.8005
• DOI: 10.1080/01616412.2016.1204495
• Languages: English
• ISSNs: 0161-6412

Abstract

Abstract : Objective: This study aimed to investigate the influence of low-intensity pure tone auditory stimulation on patients with rapid eye movement (REM), sleep behavior disorder (RBD), and attempt to identify a new method of RBD intervention. Methods: Patients diagnosed with idiopathic RBD (iRBD) or symptomatic RBD (sRBD) were given auditory stimulation of low-intensity pure tones during their REM sleep. Sleep parameters including sleep process, sleep architecture as well as eye movements (EMs) frequency, and amplitude were recorded by polysomnography monitoring at pre-, intra-, and post-stimulation. Results: Thirteen iRBD and 18 sRBD patients completed this study. Auditory stimulation significantly reduced the EMs frequency and amplitude in iRBD and sRBD patients ( p < 0.05). In the iRBD group, the intra-stimulated FSL increased significantly than the pre-stimulated FSL ( p < 0.05). After stimulation, patients had similar sleep latency (FSL), rapid eye movement sleep latency (RSL) and periodic limb movements in sleep (PLMS) compared with control. In the sRBD group, the intra-stimulated total sleep time, sleep efficiency was significantly increased, whereas the RSL and PLMS were significantly reduced compared with the pre-stimulated ones (all p < 0.05). The sRBD patients had similar time in bed, FSL and RBD episodes compared with control (all p < 0.05) in spite of significant difference before stimulation (all p < 0.05). However, the sleep architecture was not influenced by the stimulation despite the decrease in N3% in iRBD group ( p < 0.05). Conclusion: Low-intensity pure tone auditory stimulation may be a potentially effective intervention for RBD, especially for sRBD.