Biologic modulation in renal regeneration. (1st November 2016)

• Record Type: Journal Article
• Authors: Mazzinghi, Benedetta; Romagnani, Paola; Lazzeri, Elena
• Is Part Of: Expert opinion on biological therapy. Volume 16:Number 11(2016:Nov.)
• Page Start: 1403
• Page End: 1415
• Publication Date: 2016-11-01
• Subjects: Chronic renal failure -- AKI -- progression -- CKD -- tubule -- glomerulus; Gene therapy -- Periodicals; Protein drugs -- Periodicals; Peptide drugs -- Periodicals; Immunotherapy -- Periodicals; Drug delivery systems -- Periodicals; 615.5
• DOI: 10.1080/14712598.2016.1219336
• Languages: English
• ISSNs: 1471-2598

Abstract

ABSTRACT: Introduction : Chronic kidney disease (CKD) is recognized as a health care problem of increasing importance. Following the discovery of renal progenitors, the investigation of new therapeutic approaches to promote the kidney regenerative capacity has received increasing research attention. Areas covered : The authors discuss the current knowledge of glomerular regeneration by renal progenitors and the modulation of their behavior through chemical and biological agents. The regenerative capacity of renal progenitors after injury must be regulated in order to prevent an inefficient or excessive response that could lead to a failed attempt to replace lost podocytes. In addition, they discuss the most relevant pathways involved in tubular repair and how these could be modulated in order to obtain renal regeneration rather than progression of a fibrotic maladaptive response. Expert opinion : Modulation of the endogenous renal regenerative capacity is a new approach in the treatment of kidney diseases. Research efforts that concentrate on the potential regenerative capacity of the kidney can be advantageous when the experimental results are translated into clinical practice and may open the way to new therapeutic strategies for CKD.