A new anthraquinone and eight constituents from Hedyotis caudatifolia Merr. et Metcalf: isolation, purification and structural identification. Issue 19 (1st October 2016)

• Record Type: Journal Article
• Authors: Luo, Peng; Su, Jiale; Zhu, Yilin; Wei, Jianhua; Wei, Wanxing; Pan, Weigao
• Is Part Of: Natural product research. Volume 30:Issue 19(2016)
• Page Start: 2190
• Page End: 2196
• Publication Date: 2016-10-01
• Subjects: Hedyotis caudatifolia Merr. et Metcalf -- chemical constituents -- 2-hydroxy-1, 7, 8-trimethoxyanthracene -9, 10-dione; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1160231
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Hedyotis caudatifolia Merr. et Metcalf. (HC), a folk medicine in Yao nationalities areas in China, was used to investigate the chemical constituents. Through silica gel and Sephadex LH-20 column chromatography, nine compounds were isolated and purified. By physical and chemical properties, IR, MS (EI-MS, high resolution EI-MS), 1D NMR ( 1 H NMR, 13 C NMR) and 2D NMR (HSQC, 1 H– 1 H COSY, HMBC), their structures were identified as β-sitosterol (1 ), stigmasterol (2 ), scopolin (3 ), 2-hydroxy-1, 7, 8-trimethoxyanthracene-9, 10-dione (4 ), oleanolic acid (5 ), ursolic acid (6 ), methyl barbinervate (7 ), β-daucosterol (8) and p-Hydroxybenzoic acid (9 ). These compounds were isolated from HC for the first time, and4 a new anthraquinone whose biological activities are worth to be investigated in future. These compounds may contribute to the HC's pharmacological effects on treating diseases, and may be used as candidates for control index in establishing the quality control standard of HC. Abstract :