Catalyst‐Free Difunctionalization of Activated Alkenes in Water: Efficient Synthesis of β‐Keto Sulfides and Sulfones. Issue 41 (19th August 2016)

• Record Type: Journal Article
• Authors: Wang, Huamin; Wang, Guangyu; Lu, Qingquan; Chiang, Chien‐Wei; Peng, Pan; Zhou, Jiufu; Lei, Aiwen
• Is Part Of: Chemistry. Volume 22:Issue 41(2016)
• Page Start: 14489
• Page End: 14493
• Publication Date: 2016-08-19
• Subjects: aerobic oxidation -- alkenes -- ketones -- sulfides -- water; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201603041
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Difunctionalization of activated alkenes, a powerful strategy in chemical synthesis, has been accomplished for direct synthesis of a series of β‐keto sulfides and β‐keto sulfones. The transformation, mediated by O2, proceeds smoothly in water and without any catalyst. Prominent advantages of this method include mild reaction conditions, purification simplicity, and gram‐scale synthesis, underlining the practical utility of this methodology. Abstract : Keto fabulous : A catalyst‐free method has been developed for the difunctionalization of activated alkenes. Various β‐keto sulfides and β‐keto sulfones were synthesized facilely in water under an O2 atmosphere. The reaction proceeds with mild reaction conditions, simple purification and the possibility for gram‐scale synthesis.