Haematological recovery in poor and good haematopoietic stem cell mobilisers. Issue 4 (30th May 2016)

• Record Type: Journal Article
• Authors: De Santis, G. C.; Garcia‐Silva, A. C.; Chiaramonte, N. C. G.; Orellana, M. D.; Prado, B. P. A.; Oliveira, L. C.; Simões, B. P.; Covas, D. T.
• Is Part Of: Transfusion medicine. Volume 26:Issue 4(2016:Aug.)
• Page Start: 297
• Page End: 300
• Publication Date: 2016-05-30
• Subjects: haematopoietic progenitor cell -- mobilisation -- transplantation; Blood -- Transfusion -- Periodicals; 615.39
• DOI: 10.1111/tme.12324
• Languages: English
• ISSNs: 0958-7578

Abstract

SUMMARY: Objectives: Evaluate whether poor mobilisers had delayed haematopoietic (neutrophil and platelet) recovery despite receiving similar cell dose as good mobilisers. Background: Autologous haematopoietic progenitor cell (HPC) transplantation is indicated to treat some haematological malignancies. This procedure requires HPC mobilisation from bone marrow to peripheral blood. Cell dose is important for a fast haematological recovery. Despite being poor mobilisers, some patients can collect enough cell numbers for transplantation. Results: Fifteen poor mobiliser patients (peak of CD34+ cells ≤10 µL −1 in peripheral blood) were transplanted at our institution. Haematological recovery (neutrophil ≥ 500 µL −1 ) in this group was compared to that observed in the group of 16 patients of good mobilisers (peak of CD34+ cells ≥20 µL −1 in peripheral blood) who received similar cell dose (2·637 ± 0·1744 × 10 6 kg −1 vs 2·727 ± 0·1746 × 10 6 kg −1 ; P = 0·7177). The poor mobiliser group had neutrophil and platelet recovery later than the good mobiliser group (on day 12, range 9–14 vs day 10, range 9–22, P = 0·0381 for neutrophil, and on day 22·89 ± 11·16 and 14·08 ± 4·821, P = 0·0193 for platelet). Mortality rates and transfusion requirements were not different between the groups. Conclusion: Poor mobilisers have delayed neutrophil and platelet recovery after autologous HPC transplantation despite having received the same cell dose as good mobilisers.