Heterochronic neuromuscular junction development in an Australian marsupial (Macropus fuliginosus). (26th June 2016)

• Record Type: Journal Article
• Authors: Etherington, S. J.; Hong, I. H. K.; Wong, C. J. W.; Stephens, N.; Warburton, N. M.
• Is Part Of: Journal of zoology. Volume 300:Number 1(2016)
• Page Start: 27
• Page End: 35
• Publication Date: 2016-06-26
• Subjects: heterochrony -- Macropodidae -- ontogeny -- forelimb -- hindlimb -- marsupial -- motor system -- limb development; Zoology -- Periodicals; Zoologie -- Périodiques; 590.5
• DOI: 10.1111/jzo.12367
• Languages: English
• ISSNs: 0952-8369

Abstract

Abstract: The neuromuscular junction (NMJ) provides a connection between the somatic nervous and muscular systems. The present work documents, for the first time, the mature form of the NMJ in an Australian marsupial, the western gray kangaroo Macropus fuliginosus . Marsupials give birth to highly altricial young and the majority of motor system development thus occurs postnatally. We demonstrate that NMJ formation in the forelimbs of kangaroos precedes that in hindlimbs by several weeks, consistent with evidence of precocial forelimb development from other indices of motor system maturation in marsupials. Forelimb and hindlimb NMJs reach a similar level of development by the end of the first postnatal month, an outcome that results from accelerated hindlimb development in the early postnatal period together with a more unexpected stagnation or even regression of forelimb NMJ maturity over the same period. This study suggests that the pattern of NMJ maturation may be adjusted in forelimb as opposed to hindlimb. Elucidation of the underlying cellular control mechanisms may inform current understanding of NMJ formation, and as such the broader processes involved in synaptic formation. Abstract : The present work documents the mature form of the neuromuscular junction (NMJ) in the western gray kangaroo and demonstrates that NMJ formation in the forelimbs of kangaroos precedes that in hindlimbs by several weeks. Forelimb and hindlimb NMJs reach a similar level of development by the end of the first postnatal month, an outcome that results from accelerated hindlimb development in the early postnatal period together with a more unexpected stagnation or even regression of forelimb NMJ maturity over the same period.