Effect of resorption rate and osteoconductivity of biodegradable calcium phosphate materials on the acquisition of natural bone strength in the repaired bone. Issue 11 (20th July 2016)

• Record Type: Journal Article
• Authors: Chiba, Shinpei; Anada, Takahisa; Suzuki, Kentaro; Saito, Keisuke; Shiwaku, Yukari; Miyatake, Naohisa; Baba, Kazuyoshi; Imaizumi, Hideki; Hosaka, Masami; Itoi, Eiji; Suzuki, Osamu
• Is Part Of: Journal of biomedical materials research. Volume 104:Issue 11(2016)
• Page Start: 2833
• Page End: 2842
• Publication Date: 2016-07-20
• Subjects: octacalcium phosphate/gelatin composite -- β‐tricalcium phosphate -- bone strength -- resorption rate -- osteoconductivity; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.35828
• Languages: English
• ISSNs: 1549-3296

Abstract

Abstract: The purpose of this study was to compare the biodegradation rate and quality of regenerated bone among four materials. A short time period of 8 weeks was chosen to examine early bone healing. The rod‐shaped implants of commercially available two β‐tricalcium phosphate (β‐TCP) ceramics with porosity 60% and 71–80%, respectively, laboratory prepared octacalcium phosphate/gelatin composite (OCP/Gel), which has been proven to have a highly osteoconductive and biodegradable property in rat calvarial defect, and gelatin sponge (Gelatin) were implanted in rabbit tibia defect of 6 mm diameter and 7 mm depth for 2, 4 and 8 weeks. Analyses by μCT, histomorphometry and push‐in test were carried out to evaluate the extent of the tissue regeneration and the material biodegradation in the long bone. OCP/Gel and Gelatin were completely resorbed but only OCP/Gel induced cortical bone bridge until 8 weeks that has strength compatible to that of the natural bone. β‐TCP (71%‐80%) and β‐TCP (60%) were not completely resorbed and never induced the amount of new bone formation beyond that by OCP/Gel. The results indicate that the new bone having enough strength could be regenerated if the material shows not only higher biodegradation rate but also higher osteoconductivity. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2833–2842, 2016.