Oxidative stress parameters and serum magnesium levels in patients with seasonal allergic conjunctivitis. (1st October 2016)

• Record Type: Journal Article
• Authors: Dadaci, Zeynep; Oncel, Mufide; Oncel Acir, Nursen; Sahin, Emel; Borazan, Mehmet
• Is Part Of: Cutaneous and ocular toxicology. Volume 35:Number 4(2016)
• Page Start: 270
• Page End: 274
• Publication Date: 2016-10-01
• Subjects: Adjusted ischemia modified albumin -- allergy -- magnesium -- malondialdehyde -- oxidative stress -- seasonal allergic conjunctivitis; Dermatotoxicology -- Periodicals; Ocular toxicology -- Periodicals; Ocular pharmacology -- Periodicals; Dermatopharmacology -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.3109/15569527.2015.1100634
• Languages: English
• ISSNs: 1556-9527

Abstract

Abstract: Objective : To evaluate oxidative stress parameters and serum magnesium (Mg) levels in patients with seasonal allergic conjunctivitis (SAC) during the pollen season. Methods : This observational cross-sectional study involved 35 patients with SAC without any other ocular and systemic diseases, and 38 consecutive, age- and sex-matched healthy subjects. Serum malondialdehyde (MDA), adjusted ischemia modified albumin (IMA), and Mg levels were quantified, and the results were compared between the groups. Results : No significant differences were found between the groups with respect to age ( p = 0.416) and sex ( p = 0.362). Serum MDA and adjusted IMA levels of the subjects with SAC (69.54 ± 7.71 μM and 0.74 ± 0.39 ABSU) were significantly higher than the control group (64.61 ± 5.89 μM and 0.57 ± 0.19 ABSU) ( p = 0.002 and p = 0.025, respectively). There was no significant difference for serum Mg levels between the groups ( p = 0.177). Conclusion : We demonstrated higher levels of oxidative stress parameters in patients with SAC compared to the control group, which imply a possible role of oxidative stress in the pathogenesis of SAC.