Soluble urokinase plasminogen activator receptor informs on the progression course after multiple injuries. (2nd October 2016)

• Record Type: Journal Article
• Authors: Patrani, Maria; Tsaganos, Thomas; Kotzampassi, Katerina; Paraschos, Michael; Katsenos, Chrysostomos; Giamarellos-Bourboulis, Evangelos J.; Mandragos, Konstantinos
• Is Part Of: Biomarkers. Volume 21:Number 7(2016)
• Page Start: 660
• Page End: 664
• Publication Date: 2016-10-02
• Subjects: Multiple organ failure -- severe sepsis -- suPAR -- trauma; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2016.1171911
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Purpose: The purpose of this study is to study the use of soluble urokinase plasminogen activator receptor (suPAR) for the prognosis of multiple organ dysfunction (MOF) after multiple traumas. Methods: Serum suPAR was measured within the first 24 h after multiple injuries in 85 patients. Measurements were repeated after 4 d or at sepsis onset. Results: Odds ratio for trauma-associated MOF was 4.09 ( p : 0.026) with admission suPAR greater than 8 ng/ml. More than 40% increases of suPAR were associated with odds ratio 9.33 ( p : 0.047) for severe sepsis. Conclusions: suPAR is a useful surrogate biomarker for development of MOF and severe sepsis after multiple traumas.