Identification of potential biomarkers for post-traumatic complications released after trauma–hemorrhage from murine Kupffer cells and its investigation in lung and liver. (2nd October 2016)

• Record Type: Journal Article
• Authors: Schultze, Cornelia; Hildebrand, Frank; Noack, Sandra; Krettek, Christian; Zeckey, Christian; Neunaber, Claudia
• Is Part Of: Biomarkers. Volume 21:Number 7(2016)
• Page Start: 645
• Page End: 652
• Publication Date: 2016-10-02
• Subjects: Csf2rb2 -- Cxcl10 -- Gbp5 -- Il4ra -- Lcn2 -- multiple trauma; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2016.1171908
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Context: Early diagnosis of complications after severe trauma by specific biomarkers remains difficult. Objective: Identify potential new biomarkers for early diagnosis of post-traumatic complications. Material and methods: Mice underwent pressure-controlled hemorrhage or sham procedure. Four hours later, genome-wide expression of isolated Kupffer cells was compared with controls using Affymetrix-Genechip-Expression-Analysis and real-time-PCR. Results: Expression analysis and real-time-PCR revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5 . Conclusion: Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5 might represent new biomarkers for early diagnosis of post-traumatic complications, if they are linked to the development of post-traumatic complications.