Serum levels of glial fibrillary acidic protein and Nogo-A in children with autism spectrum disorders. (2nd October 2016)

• Record Type: Journal Article
• Authors: Cetin, Ihsan; Tezdig, Ihsan; Tarakcioglu, Mahmut Cem; Kadak, Muhammed Tayyib; Demirel, Omer Faruk; Ozer, Omer Faruk
• Is Part Of: Biomarkers. Volume 21:Number 7(2016)
• Page Start: 614
• Page End: 618
• Publication Date: 2016-10-02
• Subjects: Autism -- ELISA -- GFAP -- Nogo-A; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2016.1171901
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Context: Improved biomarkers would facilitate the diagnosis and treatment of autism spectrum disorders (ASD). Objective: Our objective was to examine the levels of Nogo-A and glial fibrillary acidic protein (GFAP) in children with ASD. Materials and methods: Serum concentrations of GFAP and Nogo-A were determined by enzyme-linked immunosorbent assay. Results: In this preliminary study, we found that serum Nogo-A was not found significantly different between groups, while serum levels of GFAP were significantly lower in ASD than controls. Discussion and conclusions: It will be of great interest to determine other potential causes of elevated serum levels of GFAP, and whether this elevation has any phenotypic effect.