Increased levels of oxidative stress biomarkers in metal oxides nanomaterial-handling workers. (2nd October 2016)

• Record Type: Journal Article
• Authors: Liou, Saou-Hsing; Chen, Yu-Cheng; Liao, Hui-Yi; Wang, Chien-Jen; Chen, Jhih-Sheng; Lee, Hui-Ling
• Is Part Of: Biomarkers. Volume 21:Number 7(2016)
• Page Start: 600
• Page End: 606
• Publication Date: 2016-10-02
• Subjects: Antioxidant enzyme activities -- biomarkers -- 8-hydroxydeoxyguanosine -- LC-MS/MS -- metal oxides nanomaterials; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2016.1160432
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: This study assessed oxidatively damaged DNA and antioxidant enzyme activity in workers occupational exposure to metal oxides nanomaterials. Exposure to TiO2, SiO2, and ITO resulted in significant lower antioxidant enzymes (glutathione peroxidase and superoxide dismutase) and higher oxidative biomarkers 8-hydroxydeoxyguanosine (8-oxodG) than comparison workers. Statistically significant correlations were noted between plasma and urine 8-oxodG, between white blood cells (WBC) and urine 8-oxodG, and between WBC and plasma 8-oxodG. In addition, there were significant negative correlations between WBC 8-oxodG and SOD and between urinary 8-oxodG and GPx levels. The results showed that urinary 8-oxodG may be considered to be better biomarker.