Circulating periostin level in asthmatic pregnancy. (20th October 2016)

• Record Type: Journal Article
• Authors: Ivancsó, István; Bohács, Anikó; Szalay, Balázs; Toldi, Gergely; Szilasi, Magdolna E.; Müller, Veronika; Losonczy, György; Rigó, János; Vásárhelyi, Barna; Tamási, Lilla
• Is Part Of: Journal of asthma. Volume 53:Number 9(2016)
• Page Start: 900
• Page End: 906
• Publication Date: 2016-10-20
• Subjects: Asthma -- control -- pregnancy -- periostin; Asthma -- Periodicals; 616.238005
• DOI: 10.3109/02770903.2016.1165697
• Languages: English
• ISSNs: 0277-0903

Abstract

Abstract: Objective : Asthma often complicates pregnancy and represents a risk for complications. Periostin is considered as a biomarker of asthma; however, as it also plays a role in normal gestation, pregnancy may influence circulating periostin levels. This is the first study assessing periostin in asthmatic pregnancy. Methods : Plasma periostin levels were investigated in asthma (asthmatic non-pregnant, ANP; N = 19) and asthmatic pregnancy (AP; N = 14), compared to healthy non-pregnant controls (HNP; N = 12) and healthy pregnant women (HP; N = 17). The relationship between periostin levels and asthma control determinants was also evaluated. The diagnostic efficacy of periostin to detect uncontrolled asthma was analyzed using ROC analysis. Results : Plasma periostin levels were similar in the HNP and ANP (55.68 [37.21–67.20] vs. 45.25 [32.67–64.55], p > 0.05), and elevated in the HP (68.81 [57.34–98.84] ng/mL, p = 0.02 vs. HNP) and AP groups (54.02 [44.30–74.94] ng/mL, p = 0.0346 vs. ANP). Periostin levels of the two pregnant groups were similar ( p > 0.05). In AP women periostin correlated negatively with FEV1 (r = −0.5516) and positively with Raw (r = 0.5535; both p < 0.05). Conclusions : Pregnancy itself increases circulating periostin levels and this elevation is detectable in asthmatic pregnancy as well. Although periostin correlates with lung function in asthmatic pregnancy, periostin as a biomarker has to be handled with caution in pregnant patients due to the influence of pregnancy on its plasma level.