Clinical Outcomes of Patients with Vogt–Koyanagi–Harada Disease Over 12 Years at a Tertiary Center. (2nd September 2016)

• Record Type: Journal Article
• Authors: Arevalo, J. Fernando; Lasave, Andres F.; Gupta, Vishali; Kozak, Igor; Al Harbi, Mosa Barakat; Al Rushood, Abdulaziz Adel; Al Dhibi, Hassan A.
• Is Part Of: Ocular immunology and inflammation. Volume 24:Number 5(2016)
• Page Start: 521
• Page End: 529
• Publication Date: 2016-09-02
• Subjects: Panuveitis -- prednisone -- Saudi Arabia -- uveitis -- Vogt–Koyanagi–Harada disease; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2015.1025984
• Languages: English
• ISSNs: 0927-3948

Abstract

Abstract: Purpose : To describe the clinical characteristics and treatment outcomes of Vogt–Koyanagi–Harada (VKH) disease over a 12-year period. Methods : A retrospective chart review was used to identify VKH patients, from January 1999 to December 2011. Results : In total, 154 patients (308 eyes) were diagnosed with VKH. The mean age at diagnosis was 33.8 ± 13 years. Mean baseline best-corrected visual acuity (BCVA) was 20/125; (0.8 ± 0.6 logMAR). Recurrent episodes occurred in 107 (54%) patients. Oral prednisone was administered in all patients. At the last visit, the mean BCVA was 20/50 (0.4 ± 0.7 logMAR). The most common complications post-treatment were: glaucoma [104 (33.8%) eyes] and cataract [84 (27.2%) eyes]. Conclusions : In Saudi Arabia, VKH-related uveitis is predominant in young females. Bilateral panuveitis is the most common ocular manifestation and near 50% of eyes present with exudative retinal detachment. Oral prednisone was the primary treatment and the majority of eyes maintained 20/50 or better vision.