Parkinsonism in adult-onset Rasmussens's encephalitis: a clinical picture presenting as corticobasal syndrome. (1st December 2016)

• Record Type: Journal Article
• Authors: Bilo, Leonilda; Peluso, Silvio; Antenora, Antonella; De Rosa, Anna; Esposito, Marcello; Barbato, Stefano; Pappatà, Sabina; De Michele, Giuseppe
• Is Part Of: International journal of neuroscience. Volume 126:Number 12(2016:Dec.)
• Page Start: 1136
• Page End: 1138
• Publication Date: 2016-12-01
• Subjects: Rasmussen's encephalitis -- parkinsonism -- corticobasal syndrome -- dysimmune syndrome; Nervous system -- Periodicals; 612.805
• DOI: 10.3109/00207454.2015.1135438
• Languages: English
• ISSNs: 0020-7454

Abstract

Abstract : Rasmussen's encephalitis (RE) is an immune-mediated disease, typically affecting a single cerebral hemisphere. Intractable epilepsy, hemiplegia and cognitive decline represent the clinical features; movement disorders have rarely been described. We report a case of adult-onset RE which developed hemiparkinsonism after an extraordinarily long prodromal period; to date, this is the first description of parkinsonism in RE. The association between cortical symptoms and extrapyramidal features evokes a clinical suspect of corticobasal syndrome (CBS); our patient satisfies the diagnostic criteria for possible CBS. Clinical and neuro-radiological reasons might further explain why RE accompanied by extrapyramidal signs may present as a CBS.