Irritable bowel syndrome, the microbiota and the gut-brain axis. (2nd September 2016)

• Record Type: Journal Article
• Authors: Raskov, Hans; Burcharth, Jakob; Pommergaard, Hans-Christian; Rosenberg, Jacob
• Is Part Of: Gut microbes. Volume 7:Isuse 5(2016)
• Page Start: 365
• Page End: 383
• Publication Date: 2016-09-02
• Subjects: gut-brain axis -- irritable bowel syndrome -- microbiota; Gastrointestinal system -- Microbiology -- Periodicals; Microbiology -- Periodicals; Intestine, Small -- Periodicals; 616.3
• DOI: 10.1080/19490976.2016.1218585
• Languages: English
• ISSNs: 1949-0984

Abstract

ABSTRACT: Irritable bowel syndrome is a common functional gastrointestinal disorder and it is now evident that irritable bowel syndrome is a multi-factorial complex of changes in microbiota and immunology. The bidirectional neurohumoral integrated communication between the microbiota and the autonomous nervous system is called the gut-brain-axis, which integrates brain and GI functions, such as gut motility, appetite and weight. The gut-brain-axis has a central function in the perpetuation of irritable bowel syndrome and the microbiota plays a critical role. The purpose of this article is to review recent research concerning the epidemiology of irritable bowel syndrome, influence of microbiota, probiota, gut-brain-axis, and possible treatment modalities on irritable bowel syndrome.