A novel diarylheptanoid-bearing sesquiterpene moiety from the rhizomes of Alpinia officinarum. Issue 20 (17th October 2016)

• Record Type: Journal Article
• Authors: Wei, Na; Zhou, Zhonglin; Wei, Qing; Wang, Yong; Jiang, Jun; Zhang, Junqing; Wu, Lixiang; Dai, Shuiping; Li, Youbin
• Is Part Of: Natural product research. Volume 30:Issue 20(2016)
• Page Start: 2344
• Page End: 2349
• Publication Date: 2016-10-17
• Subjects: Alpinia officinarum Hance -- Alpinisin A -- cytotoxicity activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2016.1185716
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new diarylheptanoid analogue-bearing sesquiterpene moiety, named Alpinisin A, was isolated from the rhizomes of Alpinia officinarum Hance. The new structure was determined by various spectroscopic techniques 1 H-nuclear magnetic resonance ( 1 H NMR), 13 C-attached proton test ( 13 C-APT), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), 1 H- 1 H correlation spectroscopy ( 1 H– 1 HCOSY), nuclear overhauser effect spectroscopy (NOESY) and high resolution electrospray ionization mass spectrometry (HR–ESI–MS). The compound was tested for cytotoxic activity in vitro against human tumour cell lines (gastric carcinoma cell -7901 (SGC-7901), Michigan Cancer Foundation-7 (MCF-7) and Caski), which showed significant inhibitory effects with IC50 levels of 11.42, 15.14 and 14.78 μM, respectively. The novel chemical structure characterised with a diarylheptanoid linked to a chain-like sesquiterpenoid should be highlighted. Abstract :