Four new taraxastane-type triterpenoic acids from Cirsium setosum. Issue 11 (1st November 2016)

• Record Type: Journal Article
• Authors: Luan, Na; Wei, Wen-Di; Wang, Ali; Wu, Xiu-Li; Qi, Yan; Li, Jin-Jie; Zheng, Jian-Quan; Shang, Xiao-Ya
• Is Part Of: Journal of Asian natural products research. Volume 18:Issue 11(2016)
• Page Start: 1015
• Page End: 1023
• Publication Date: 2016-11-01
• Subjects: Compositae -- Cirsium setosum -- taraxastane-type triterpenoids acids -- absolute configuration -- cytotoxic activities; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2016.1217519
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Four new taraxastane-type triterpenoids acids 3 β, 22 α -dihydroxy-20-taraxasten-30-oic acid (1 ), 3 β -hydroxy-22-oxo-20-taraxasten-30-oic acid (2 ), 3-oxo-22 α -hydroxy-20- taraxasten-30-oic acid (3 ), and 3β, 19β-dihydroxy-20-taraxasten-30-oic acid (4 ) were isolated and characterized from Cirsium setosum (Willd.) MB. Their structures were determined by the combination of 1D and 2D NMR experiments ( 1 H- 1 HCOSY, HSQC, HMBC and ROESY) and mass spectrometry. Compound2 exhibited potent selective cytotoxicity against human ovarian cancer cell line A2780 with an IC50 value of 3.9 μM.