Cycloartane triterpenes from Beesia calthaefolia and their anticomplement structure–activity relationship study. Issue 11 (1st November 2016)

• Record Type: Journal Article
• Authors: Mu, Li-Hua; Zhao, Jin-Yuan; Zhang, Jing; Liu, Ping
• Is Part Of: Journal of Asian natural products research. Volume 18:Issue 11(2016)
• Page Start: 1101
• Page End: 1107
• Publication Date: 2016-11-01
• Subjects: Beesia calthaefolia -- cycloartane glycoside -- anticomplement activity -- structure–activity relationship; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2016.1174698
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Fifteen cycloartane triterpenes were isolated from Beesia calthaefolia and among them one was new cycloartane triterpenoid. The structure of new compound was determined by the application of spectroscopic analyses and chemical methods. The fifteen compounds were evaluated for their anticomplement activity by classic pathway. The structure–activity relationship analysis indicated that the configurations of 12-OH is preferable to be α than β, and 18-OH can decrease while 15-OH can increase the anticomplement activity, but saponin with both 15-OH and 18-OH lost most of its activity. The glycosyl moiety of most isolated cycloartane triterpenes is xylosyl. When xylosyl was substituted by glucosyl or galactosyl, their anticomplement activities were decreased or increased, respectively. Further structure–activity relationship (SAR) studies must be carried out to achieve general conclusions regarding the effect of further functionalizations on the anticomplement saponins.