Clinical Significance of Circulating Osteopontin Levels in Patients With Lung Cancer and Correlation With VEGF and MMP-9. (13th September 2016)

• Record Type: Journal Article
• Authors: Kerenidi, Theodora; Kazakou, Aikaterini P.; Lada, Martha; Tsilioni, Irini; Daniil, Zoe; Gourgoulianis, Konstantinos I.
• Is Part Of: Cancer investigation. Volume 34:Number 8(2016)
• Page Start: 385
• Page End: 392
• Publication Date: 2016-09-13
• Subjects: Prognostic studies -- cancer biomarkers -- lung cancer -- angiogenesis; Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.1080/07357907.2016.1223301
• Languages: English
• ISSNs: 0735-7907

Abstract

ABSTRACT: Osteopontin (OPN) is a multifunctional cytokine involved in carcinogenesis. Serum levels of OPN, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-9 (MMP-9) were measured by ELISA in 90 lung cancer patients. OPN levels were elevated in patients compared to controls ( p <.0001). Smokers, patients with worse performance status, and weight loss exhibited higher OPN levels ( p =.0012, .00036, and.0003, respectively). Increased OPN levels were associated with worse survival ( p =.0018). Finally, OPN levels were positively correlated with both VEGF ( p =.0008) and MMP-9 ( p <.0001). OPN might serve as a prognostic biomarker, and the positive correlation between OPN and both VEGF and MMP-9 could implicate new insights in tumor angiogenesis.