Synthesis and investigation of antimicrobial activity of compounds derived from benzo[C][1, 2, 5]oxadiazole-1-oxides and phenolates. Issue 18 (16th September 2016)

• Record Type: Journal Article
• Authors: Chugunova, Elena A.; Akylbekov, Nurgali I.; Voloshina, Alexandra D.; Kulik, Natalia V.; Zobov, Vladimir V.; Babaev, Vasily M.; Gavrilov, Nikolai V.; Burilov, Alexander R.
• Is Part Of: Synthetic communications. Volume 46:Issue 18(2016)
• Page Start: 1560
• Page End: 1565
• Publication Date: 2016-09-16
• Subjects: Antimicrobial activity -- benzofuroxan -- C-bonded product -- dual action -- phenolates; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2016.1213295
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: (Di)chloro(di)nitrobenzofuroxans form substitution products involving carbon atoms with phenolates in isopropyl alcohol medium. In the case of 4, 6-dinitro-5, 7-dichlorobenzofuroxan, besides replacement of one chlorine atom and the formation of C -bonded product, we observed the hydrolysis of the second chlorine and replacement of it by hydroxyl group. Products of reaction of 4, 6-dichloro-5-nitrobenzofuroxan with phenolates display excellent antimicrobial activity and have dual action, both against bacteria and fungi. GRAPHICAL ABSTRACT: