New 3D and 2D supramolecular heteroleptic palladium(II) dithiocarbamates as potent anticancer agents. Issue 20 (17th October 2016)

• Record Type: Journal Article
• Authors: Khan, Shahan Zeb; Amir, Muhammad Kashif; Abbasi, Rashda; Tahir, Muhammad Nawaz; Zia-ur-Rehman,
• Is Part Of: Journal of coordination chemistry. Volume 69:Issue 20(2016)
• Page Start: 2999
• Page End: 3009
• Publication Date: 2016-10-17
• Subjects: Mixed-ligand palladium complexes -- supramolecular -- anticancer -- oxidative stress -- DNA-ladder analysis; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2016.1225198
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: Three new heteroleptic palladium(II) dithiocarbamates with better in vitro anticancer activity than cisplatin were synthesized and characterized by different analytical techniques, elemental analysis, FTIR, NMR, and single crystal X-ray diffraction analysis. The Pd center is chelated by dithiocarbamate ligand {4-benzylpiperazine-1-carbodithioate (1 ) and (3 ) or (4-(2-methoxyphenyl)piperazine-1-carbodithioate (2 )}, triorganophosphine { tris -(4-flourophenyl)-phosphine (1 ) and (2 ) or tris -(4-chlorophenyl)phosphine (3 )}, and a chloro-group, resulting in a square planar geometry. The packing diagram reveals a 3D network (1 and2 ) and a 2D network (3 ) composed of various 1D chains in which the molecules are linked via hydrogen bonds (1–3 ) and halide⋯π (1, 3 ) interactions. The anticancer activities of complexes against HeLa cell line varies in the sequence2 (23.438 μM) > 1 (38.293 μM) > 3 (47.554 μM) > cis platin (78.075 μM). The cytotoxicity of these complexes is due to their strong induction of oxidative stress and DNA-damage ability leading to apoptosis. Abstract :