Injectable cationic hydrogels with high antibacterial activity and low toxicity. Issue 36 (26th August 2016)

• Record Type: Journal Article
• Authors: Du, Hong; Wang, Ying; Yao, Xuxia; Luo, Qiaojie; Zhu, Weipu; Li, Xiaodong; Shen, Zhiquan
• Is Part Of: Polymer chemistry. Volume 7:Issue 36(2016)
• Page Start: 5620
• Page End: 5624
• Publication Date: 2016-08-26
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c6py01346e
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : We prepared injectable cationic hydrogels with strong antibacterial activity and remarkably low toxicity by in situ thiol–ene "click" reaction between dimethacrylate terminated poly(hexamethylene guanidine) (PHMGDMA) and poly[oligo(ethylene) glycol mercaptosuccinate] (POEGMS) under physiological conditions. Abstract : Antibacterial materials have always suffered from high toxicity. In this study, we fabricated injectable and biodegradable hydrogels utilizing poly(hexamethylene guanidine) hydrochloride and poly(ethylene glycol) as the backbone through a thiol–ene "click" reaction under physiological conditions, and they showed remarkably low toxicity and high and broad-spectrum antibacterial activity.