Advances in the development of catalytic tethering directing groups for C–H functionalization reactions. Issue 36 (10th August 2016)

• Record Type: Journal Article
• Authors: Sun, Huan; Guimond, Nicolas; Huang, Yong
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 36(2016)
• Page Start: 8389
• Page End: 8397
• Publication Date: 2016-08-10
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob01258b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Inspired by the development of organocatalysis, transition-metal-catalyzed C–H functionalization reactions using tethering groups to accomplish site-selectivity catalytically have been demonstrated. Abstract : Transition metal-catalyzed C–H bond insertion is one of the most straightforward strategies to introduce functionalities within a hydrocarbon microenvironment. For the past two decades, selective activation and functionalization of certain inert C–H bonds have been made possible with the help of directing groups (DGs). Despite the enormous advances in the field, an overwhelming majority of systems require two extra steps from their simple precursors: installation and removal of the DGs. Recently, traceless and multitasking groups were invented as a partial solution to DG release. However, installation remains largely unsolved. Ideally, a transient, catalytic DG would circumvent this problem and increase the step- and atom-economy of C–H functionalization processes. In this review, we summarize the recent development of the transient tethering strategy for C–H activation reactions.