Synthesis of trifluoromethylthiolated pyridinones through the copper-mediated trifluoromethylthiolation of iodopyridinones. Issue 36 (26th August 2016)

• Record Type: Journal Article
• Authors: Luo, Beibei; Zhang, Yunxiao; You, Yi; Weng, Zhiqiang
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 36(2016)
• Page Start: 8615
• Page End: 8622
• Publication Date: 2016-08-26
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob01348a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A simple method for the synthesis of trifluoromethylthiolated pyridinones through the copper-mediated trifluoromethylthiolation of iodopyridinones was developed. Abstract : An operationally simple method for the copper-mediated trifluoromethylthiolation of iodopyridinones employing (bpy)CuSCF3 (1 ; bpy = 2, 2′-bipyridine) as a trifluoromethylthiolating reagent is presented. Various types of iodopyridinones are applicable and the trifluoromethylthiolated pyridinones are obtained in moderate to excellent yields. This method tolerates a variety of protecting groups on the nitrogen atom of pyridinones. In addition, scalability of the reaction is demonstrated.