Merging photoredox with copper catalysis: decarboxylative difluoroacetylation of α, β-unsaturated carboxylic acids with ICF2CO2Et. Issue 79 (13th September 2016)

• Record Type: Journal Article
• Authors: Zhang, Heng-Rui; Chen, Dao-Qian; Han, Ya-Ping; Qiu, Yi-Feng; Jin, Dong-Po; Liu, Xue-Yuan
• Is Part Of: Chemical communications. Volume 52:Issue 79(2016)
• Page Start: 11827
• Page End: 11830
• Publication Date: 2016-09-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc06284a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel decarboxylative difluoroacetylation of α, β-unsaturated carboxylic acids via a combination of visible light photocatalysis and cooper catalysis is reported. Abstract : A photoredox-/copper-catalyzed decarboxylative difluoroacetylation reaction of α, β-unsaturated carboxylic acids has been developed. This reaction produces a variety of difluoroalkylated alkenes in moderate to excellent yields and exhibits satisfactory stereoselectivity and a broad substrate scope at ambient temperature. Furthermore, this decarboxylative difluoroacetylation protocol provides efficient and environment friendly access to the difluoroalkylated alkenes.