Alloying barbituric and thiobarbituric acids: from solid solutions to a highly stable keto co-crystal form. Issue 79 (13th September 2016)

• Record Type: Journal Article
• Authors: Shemchuk, O.; Braga, D.; Grepioni, F.
• Is Part Of: Chemical communications. Volume 52:Issue 79(2016)
• Page Start: 11815
• Page End: 11818
• Publication Date: 2016-09-13
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc06615a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Alloying isomorphous barbituric and thiobarbituric acids yields solid solutions of formula BA x TBA1− x ( x < 0.8); for x = 0.5 the isomorphous, stable keto co-crystal BA0.5 TBA0.5 is observed, which melts at 265 °C, i.e. ca. 10 and 20 °C higher than the melting points of BA and TBA. Abstract : Alloying isomorphous crystals of barbituric acid (BA) and thiobarbituric acid (TBA) yields solid solutions of general formula BA x TBA1− x ( x < 0.8); for x = 0.5 the stable co-crystal BA0.5 TBA0.5, isomorphous with the parent keto forms, is observed, which melts at 265 °C, i.e. ca. 10 and 20 °C higher than the melting points of BA and TBA, respectively. While the BA x TBA1− x solid solutions with x > 0.5 are stable, those with x < 0.5 convert, with time or temperature, to the BA0.5 TBA0.5 co-crystal.