A lysosome-targeted fluorescent sensor for the detection of glutathione in cells with an extremely fast response. Issue 77 (7th September 2016)

• Record Type: Journal Article
• Authors: Huang, Rong; Wang, Bei-Bei; Si-Tu, Xing-Ming; Gao, Tao; Wang, Fang-Fang; He, Huan; Fan, Xiao-Yang; Jiang, Feng-Lei; Liu, Yi
• Is Part Of: Chemical communications. Volume 52:Issue 77(2016)
• Page Start: 11579
• Page End: 11582
• Publication Date: 2016-09-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc06750f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A Rhodamine B-based off–on fluorescent sensor (RhB-1 ) for GSH has an extremely fast detection response time of 10 s in aqueous solutions. Abstract : A highly sensitive and selective Rhodamine B-based fluorescent sensor, RhB-1, for glutathione (GSH) was easily synthesized. An extremely fast detection response time of 10 s, which is the fastest one ever reported, is achieved in aqueous solutions over a wide pH range with large enhancement of emission intensity. The sensor detects GSH in cells and selectively accumulates in lysosomes.