"Smart" drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry. Issue 74 (23rd August 2016)

• Record Type: Journal Article
• Authors: Shi, Liyang; Han, Yuanyuan; Hilborn, Jöns; Ossipov, Dmitri
• Is Part Of: Chemical communications. Volume 52:Issue 74(2016)
• Page Start: 11151
• Page End: 11154
• Publication Date: 2016-08-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc05565f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A new self-healing hydrogel is developed using dynamic coordinate bonds between drug loaded MgSiO3 nanoparticles and bisphosphonate functionalized hyaluronic acid. The nanocomposite network is stable at neutral pH, but is disassembled in an acidic environment, providing "smart" drug release. Abstract : We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium–bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.