High kinetic inertness of a bis-hydrated Gd-complex with a constrained AAZTA-like ligand. Issue 75 (25th August 2016)

• Record Type: Journal Article
• Authors: Vágner, Adrienn; Gianolio, Eliana; Aime, Silvio; Maiocchi, Alessandro; Tóth, Imre; Baranyai, Zsolt; Tei, Lorenzo
• Is Part Of: Chemical communications. Volume 52:Issue 75(2016)
• Page Start: 11235
• Page End: 11238
• Publication Date: 2016-08-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc04753j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The Gd III complex of a cyclohexyl-fused AAZTA derivative shows the highest kinetic inertness in the class of non-macrocyclic bis hydrated Gd III -complexes and optimal relaxometric performances. Abstract : Kinetic inertness is a key property for a Gd-based contrast agent. The Gd III complex of a cyclohexyl-fused AAZTA derivative shows the highest kinetic inertness for non-macrocyclic bis hydrated ( q = 2) Gd III -complexes with a dissociation half-life of 91 years under physiological conditions, very close to that of macrocyclic clinically approved contrast agents. It also shows optimal relaxometric performance ( r 1 = 8.3 mM −1 s −1 at 20 MHz and 25 °C) due to the presence of two inner sphere water molecules in fast exchange with bulk water and not displaced by endogenous anions.