Synthesis, spectral characterization, and antituberculosis activity of thiazino[3, 2-A]benzimidazole derivatives. (2nd July 2016)

• Record Type: Journal Article
• Authors: Gong, Jing-Xu; He, Ya; Cui, Zhen-Lin; Guo, Yue-Wei
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 191:Number 7(2016)
• Page Start: 1036
• Page End: 1041
• Publication Date: 2016-07-02
• Subjects: Thiazino-benzimidazole derivatives -- synthesis -- crystal structure -- anti-TB activity; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2015.1135149
• Languages: English
• ISSNs: 1042-6507

Abstract

ABSTRACT: A series of novel thiazino[3, 2-a]benzimidazole derivatives synthesized by cyclization of (R)-2-(chloromethyl)oxirane with benzimidazole-2-thiol followed by reacted with benzyl bromides in high yield under milder conditions. The molecular structures of all compounds were confirmed by 1 H and 13 C NMR spectroscopy and Mass spectrometry. The absolute configuration of the compounds was confirmed by X-ray diffraction analysis. All the synthesized compounds were evaluated in vitro for their antituberculosis activity. GRAPHICAL ABSTRACT: