Green and catalyst-free synthesis of olsalazine analogs. Issue 2 (2nd April 2016)

• Record Type: Journal Article
• Authors: Ibrahim, Mohamed A.; Elagawany, Mohamed; Ibrahim, Tarek S.
• Is Part Of: Green chemistry letters and reviews. Volume 9:Issue 2(2016)
• Page Start: 91
• Page End: 95
• Publication Date: 2016-04-02
• Subjects: Mesalazine dimer -- olsalazine -- IBD -- Green chemistry -- benzotriazole; Green chemistry -- Periodicals; 540
• DOI: 10.1080/17518253.2016.1163421
• Languages: English
• ISSNs: 1751-8253

Abstract

ABSTRACT: A greener protocol for the synthesis of olsalazine analogs is reported. Olsalazine analogs are prepared in high yields by a one-pot reaction of two molecules of mesalazine with benzotriazole-activated aspartic acid and glutamic acid in water under microwave irradiation. GRAPHICAL ABSTRACT: A greener protocol for the synthesis of olsalazine analogs is reported. Olsalazine analogs are prepared in high yields by a one-pot reaction of two molecules of mesalazine and aspartic/glutamic benzotriazoles in water under microwave irradiation.