Efficacy of phytosterols and fish-oil supplemented high-oleic-sunflower oil rich diets in hypercholesterolemic growing rats. (18th May 2016)

• Record Type: Journal Article
• Authors: Alsina, Estefania; Macri, Elisa V.; Lifshitz, Fima; Bozzini, Clarisa; Rodriguez, Patricia N.; Boyer, Patricia M.; Friedman, Silvia M.
• Is Part Of: International journal of food sciences and nutrition. Volume 67:Number 4(2016)
• Page Start: 441
• Page End: 453
• Publication Date: 2016-05-18
• Subjects: Body fat -- bone quality -- fish oil -- high-oleic-sunflower oil -- lipid profile -- phytosterol -- weight and growth gain; Food -- Analysis -- Periodicals; Nutrition -- Periodicals; 641.3
• DOI: 10.3109/09637486.2016.1161010
• Languages: English
• ISSNs: 0963-7486

Abstract

Abstract: Phytosterols (P) and fish-oil (F) efficacy on high-oleic-sunflower oil (HOSO) diets were assessed in hypercholesterolemic growing rats. Controls (C) received a standard diet for 8 weeks; experimental rats were fed an atherogenic diet (AT) for 3 weeks, thereafter were divided into four groups fed for 5 weeks a monounsaturated fatty acid diet (MUFA) containing either: extra virgin olive oil (OO), HOSO or HOSO supplemented with P or F. The diets did not alter body weight or growth. HOSO-P and HOSO-F rats showed reduced total cholesterol (T-chol), non-high-density lipoprotein-cholesterol (non-HDL-chol) and triglycerides and increased HDL-chol levels, comparably to the OO rats. Total body fat (%) was similar among all rats; but HOSO-F showed the lowest intestinal, epididymal and perirenal fat. However, bone mineral content and density, and bone yield stress and modulus of elasticity were unchanged. Growing hypercholesterolemic rats fed HOSO with P or F improved serum lipids and fat distribution, but did not influence material bone quality.