Essential oil composition and biological activity from Artemisia caerulescens subsp. densiflora (Viv.) Gamisans ex Kerguélen & Lambinon (Asteraceae), an endemic species in the habitat of La Maddalena Archipelago. Issue 16 (17th August 2016)

• Record Type: Journal Article
• Authors: Ornano, Luigi; Venditti, Alessandro; Ballero, Mauro; Sanna, Cinzia; Donno, Yuri; Quassinti, Luana; Bramucci, Massimo; Vitali, Luca A.; Petrelli, Dezemona; Tirillini, Bruno; Papa, Fabrizio; Maggi, Filippo; Bianco, Armanodoriano
• Is Part Of: Natural product research. Volume 30:Issue 16(2016)
• Page Start: 1802
• Page End: 1809
• Publication Date: 2016-08-17
• Subjects: Artemisia caerulescens subsp. densiflora Viv. -- davana ethers -- davanone -- (E)-nerolidol -- β-oplopenone -- cis-sabinene -- terpinen-4-ol; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1079190
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract : The purpose of this study was to investigate the composition of the essential oil obtained from a population of Artemisia caerulescens subsp. densiflora growing in Razzoli, an island in the La Maddalena Archipelago (Sardinia, Italy). A. caerulescens sups. densiflora Viv. (Asteraceae), a wild herb, seldom studied in the Mediterranean, represents one of the many rare endemic species growing in North Sardinia. The essential oil composition was analysed by means of GC/MS analysis, which showed davana ethers as the major volatile components, accounting together for 17.5%, followed by (E)-nerolidol (4.5%), β -oplopenone (3.3%), cis-sabinene hydrate (5.2%) and terpinen-4-ol (4.7%). The oil was tested for antioxidant activity by means of DPPH test, inhibition of lipid oxidation test and hypochlorous acid test, which showed a quite interesting scavenger capacity. For the first time, we reported the cytotoxic activity of the essential oil of A. caerulescens subsp. densiflora, against three human tumour cell lines (A375, MDA-MB231 and HCT116), with IC50 values in the range 5.20–7.61 μg/mL, which deserved further studies to support its use as chemopreventive agent. Finally, the antimicrobial activity of the essential oil, displayed on a panel of human pathogens, was very low. Graphical abstract: Artemisia caerulescens subsp. densiflora (Viv.) Gamisans ex Kerguélen & Lambinon (Asteraceae)