Anticholinesterases and antioxidant alkamides from Piper nigrum fruits. Issue 17 (1st September 2016)

• Record Type: Journal Article
• Authors: Tu, Yanbei; Zhong, Yujiao; Du, Hongjian; Luo, Wei; Wen, Yaya; Li, Qin; Zhu, Chao; Li, Yanfang
• Is Part Of: Natural product research. Volume 30:Issue 17(2016)
• Page Start: 1945
• Page End: 1949
• Publication Date: 2016-09-01
• Subjects: Piper nigrum -- alkamides -- anticholinesterase -- antioxidant -- Aβ1–42 aggregation inhibition; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1089243
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The anticholinesterase and antioxidant effects of five different extracts of Piper nigrum were evaluated. Twenty-one known alkamides were isolated from active ethyl acetate extract and investigated for their cholinesterase inhibitory and antioxidant effects. Among them, piperine (2 ), piperettine (5 ) and piperettyline (20 ) exhibited dual inhibition against AChE and BChE, and feruperine (18 ) was the most potent selective inhibitor of BChE. Molecular docking simulation was performed to get insight into the binding interactions of the ligands and enzymes. In addition, N -trans-feruloyltyramine (3 ) contributed to the strongest DPPH radical-scavenging activity. The self-induced A β aggregation inhibition of2, 5 and18 was further evaluated. Results indicated that some alkamides could be multifunctional lead candidates for Alzheimer's disease therapy. Graphical abstract: