Cytotoxic activity and molecular docking of a novel biflavonoid isolated from Jacaranda acutifolia (Bignoniaceae). Issue 18 (16th September 2016)

• Record Type: Journal Article
• Authors: Mostafa, Nada M.; Ashour, Mohamed L.; Eldahshan, Omayma A.; Singab, Abdel Nasser B.
• Is Part Of: Natural product research. Volume 30:Issue 18(2016)
• Page Start: 2093
• Page End: 2100
• Publication Date: 2016-09-16
• Subjects: Jacaranda acutifolia -- Bignoniaceae -- biflavonoid -- cytotoxic activity -- molecular docking; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1114938
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A novel biflavonoid [kaempferol (6→8″) apigenin] was isolated from the leaves of Jacaranda acutifolia . The structure was elucidated based on chemical evidence, 1D and 2D spectroscopic analyses as well as spectrometric techniques. The compound showed promising cytotoxic activity against breast cancer cell line MCF-7. The anticancer activity was explained via virtual docking of the isolated compound to the main sites in the human cyclin-dependent kinase2 (CDK2) crystal structure. Abstract :