Decellularized Cartilage Microparticles: Dissociated and Reconstituted Cartilage Microparticles in Densified Collagen Induce Local hMSC Differentiation (Adv. Funct. Mater. 30/2016). (8th August 2016)

• Record Type: Journal Article
• Authors: Novak, Tyler; Seelbinder, Benjamin; Twitchell, Celina M.; Voytik‐Harbin, Sherry L.; Neu, Corey P.
• Is Part Of: Advanced functional materials. Volume 26:Number 30(2016)
• Page Start: 5426
• Page End: 5426
• Publication Date: 2016-08-08
• Subjects: 3D microenvironments -- differentiation -- guanidine hydrochloride -- mesenchymal stem cells -- reduction and reconstitution; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201670195
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : On page 5427, C. P. Neu and co‐workers report on successfully combining the benefits of native tissue biochemistry/structure with the tunability of reconstituted biomaterials for the formation of clinically relevant tissue composites. Native articular cartilage and reconstituted type I collagen form a moldable 'cartilage clay' that can be custom designed to meet the mechanical, biochemical, and geometric needs of a clinical implant; showing the capability to locally differentiate progenitor cells.