A unique presentation of acute liver failure from herpes simplex virus hepatitis. Issue 4 (29th July 2016)

• Record Type: Journal Article
• Authors: Gutierrez, C.; Kebriaei, P.; Turner, K.A.; Yemelyanova, A.; Ariza‐Heredia, E.J.; Foo, W.C.
• Is Part Of: Transplant infectious disease. Volume 18:Issue 4(2016)
• Page Start: 592
• Page End: 594
• Publication Date: 2016-07-29
• Subjects: acute liver failure -- herpes simplex virus -- hepatitis -- liver microabscesses -- acyclovir; Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12556
• Languages: English
• ISSNs: 1398-2273

Abstract

Abstract: We present the case of a patient, with history of myelodysplastic syndrome and recent bone marrow transplant, who developed fulminant liver failure secondary to herpes simplex virus (HSV) hepatitis. His presentation was unique, as findings of liver microabscesses on computed tomography scan have not been described previously in this patient population. Despite initial treatment with acyclovir, he continued to deteriorate, and later sensitivities found the HSV strain to be resistant to acyclovir. HSV hepatitis with secondary liver failure is rare and, without appropriate treatment, its mortality is >80%. Early suspicion and immediate therapy are the keys to improve patient survival.