Messages from forgotten friends: classic cell adhesion molecules inhibit regeneration too. (12th July 2016)

• Record Type: Journal Article
• Authors: Danzi, Matt C; Lemmon, Vance P
• Is Part Of: EMBO journal. Volume 35:Number 16(2016)
• Page Start: 1721
• Page End: 1723
• Publication Date: 2016-07-12
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201694938
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : A necessary step toward complete functional recovery after spinal cord injury is the regeneration of axons. Axon regrowth after injury is prevented by a myriad of intrinsic and extrinsic factors. In this issue of The EMBO Journal, Huang et al (2016 ) demonstrate that the cell adhesion molecule NB‐3 (CNTN6) functions as a major brake on axon regrowth when it is activated by NB‐3 from scar‐forming cells at the injury site. Disruption of this NB‐3 trans ‐cellular signaling led to impressive axon regrowth after spinal cord transection. Abstract : Trans ‐cellular signaling between neurons and scar‐forming cells mediated by the adhesion molecule NB‐3 constitutes one of the brakes that inhibits axon regeneration following spinal cord injury.