The effects of different lipid emulsions on the lipid profile, fatty acid composition, and antioxidant capacity of preterm infants: A double-blind, randomized clinical trial. Issue 5 (October 2016)

• Record Type: Journal Article
• Authors: Wang, Ying; Feng, Yi; Lu, Li-Na; Wang, Wei-Ping; He, Zhen-Juan; Xie, Li-Juan; Hong, Li; Tang, Qing-Ya; Cai, Wei
• Is Part Of: Clinical nutrition. Volume 35:Issue 5(2016:Oct.)
• Page Start: 1023
• Page End: 1031
• Publication Date: 2016-10
• Subjects: Lipid emulsion -- Parenteral nutrition -- Fatty acids -- Lipid profile -- Oxidative stress; ALA α-linolenic acid -- ApoaI apolipoprotein aI -- Apob apolipoprotein b -- ARA arachidonic acid -- BUN blood urea nitrogen -- Cr creatinine -- DHA docosahexaenoic acid -- EN enteral nutrition -- EPA eicosapentaenoic acid -- EFA essential fatty acids -- GSH-PX glutathione peroxidase -- GGT gamma glutamyltransferase -- Hb hemoglobin -- HDL high density lipoprotein -- LA linoleic acid -- LCT long-chain triacylglycerols -- LDL low density lipoprotein -- LP(a) lipoprotein (a) -- MDA malondialdehyde -- MCT media-chain triacylglycerols -- MUFA monounsaturated fatty acid -- OO olive oil -- PN parenteral nutrition -- PLT platelets -- PUFA polyunsaturated fatty acid -- RBC red blood cell -- SOD superoxide dismutase -- T-AOC total-anti-oxidizing-capability -- TC total cholesterol -- TG triglyceride -- WBC white blood cell; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2015.10.011
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Olive oil (OO), medium-chain triglycerides (MCT)/long-chain triglycerides (LCT) mixture and soybean oil (SO) lipid emulsions are currently used for preterm infants in China. The aim of our study was to compare the lipid profile, fatty acid composition, and antioxidant capacity of preterm infants administered OO, MCT/LCT, or SO lipid emulsions. Methods: In this study, 156 preterm infants (birth weight < 2000 g and gestational age < 37 weeks) received parenteral nutrition (PN) containing OO, MCT/LCT, or SO lipid emulsions for a minimum of 14 d. On days 0, 7, and 14, the lipid profile, fatty acid composition and antioxidant capacity were analyzed. Results: On day 7, HDL levels in the MCT/LCT group were significantly lower than in the OO (1.06 ± 0.40 mmol/L) or SO groups. LDL levels were higher in the OO group than in the MCT/LCT or SO groups on day 7. A-I/B was higher in MCT/LCT than in OO or SO groups. Myristic acid (C14:0) levels on days 7 and 14 increased in MCT/LCT compared to the OO and SO groups. The OO group had higher oleic acid (C18:1n9) levels than the two other groups. Linoleic acid (C18:2n6), linolenic acid (C18:3n3), and eicosapentaenoic acid (20:5n3) were significantly lower in the OO group than in MCT/LCT or SO groups. Monounsaturated fatty acid levels decreased, and ω-6 polyunsaturated fatty acid and essential fatty acids levels increased in MCT/LCT and SO groups. No significant differences were obtained in SOD, MDA, GSH-Px, and T-AOC among the groups. Conclusion: The three lipid emulsions were safe and well tolerated in preterm infants. Oleic acid (C18:1n9) levels increased and LA (C18:2n6), ALA (C18:3n3), and EPA (C20:5n23) levels decreased in OO compared to MCT/LCT or SO. Clinical trial registration number:NCT01683162, https://register.clinicaltrials.gov/ .