Glycans and the platelet life cycle. (17th August 2016)

• Record Type: Journal Article
• Authors: Li, Renhao; Hoffmeister, Karin M.; Falet, Hervé
• Is Part Of: Platelets. Volume 27:Number 6(2016)
• Page Start: 505
• Page End: 511
• Publication Date: 2016-08-17
• Subjects: GPIbα -- platelet clearance -- Ashwell-Morell receptor -- sialic acid; Blood platelets -- Periodicals; Blood Platelets -- Periodicals; 615.39
• DOI: 10.3109/09537104.2016.1171304
• Languages: English
• ISSNs: 0953-7104

Abstract

Abstract: Platelet numbers are intricately regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A recent study in mice identified a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes. This new finding generated renewed interest in platelet clearance mechanisms. Here, different established and emerging mechanisms of platelet senescence and clearance will be reviewed with specific emphasis on the role of posttranslational modifications.