Catalase‐Loaded TaOx Nanoshells as Bio‐Nanoreactors Combining High‐Z Element and Enzyme Delivery for Enhancing Radiotherapy. Issue 33 (8th June 2016)

• Record Type: Journal Article
• Authors: Song, Guosheng; Chen, Yuyan; Liang, Chao; Yi, Xuan; Liu, Jingjing; Sun, Xiaoqi; Shen, Sida; Yang, Kai; Liu, Zhuang
• Is Part Of: Advanced materials. Volume 28:Issue 33(2016)
• Page Start: 7143
• Page End: 7148
• Publication Date: 2016-06-08
• Subjects: bio‐nanoreactors -- enzyme delivery -- hypoxia -- radiotherapy -- tantalum oxide; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201602111
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : A novel type of bio‐nanoreactor with catalase loaded inside TaOx hollow nanoshells is fabricated via a mild one‐step method. Such bio‐nanoreactors could efficiently improve the tumor oxygenation by supplying oxygen via decomposition of endogenic H2 O2 in a tumor microenvironment, and thus synergistically enhance the efficacy of cancer radiotherapy by both depositing radiation energy within the tumor and overcoming hypoxia‐induced radiotherapy resistance.