Towards a DNA Nanoprocessor: Reusable Tile‐Integrated DNA Circuits. Issue 35 (19th July 2016)

• Record Type: Journal Article
• Authors: Gerasimova, Yulia V.; Kolpashchikov, Dmitry M.
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 35(2016)
• Page Start: 10244
• Page End: 10247
• Publication Date: 2016-07-19
• Subjects: crossover DNA tiles -- DNA logic gates -- molecular beacons -- molecular computation -- NOR gates; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201603265
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Modern electronic microprocessors use semiconductor logic gates organized on a silicon chip to enable efficient inter‐gate communication. Here, arrays of communicating DNA logic gates integrated on a single DNA tile were designed and used to process nucleic acid inputs in a reusable format. Our results lay the foundation for the development of a DNA nanoprocessor, a small and biocompatible device capable of performing complex analyses of DNA and RNA inputs. Abstract : AND and NOR on DNA : Arrays of communicating DNA logic gates integrated in a single DNA tile were produced. The gates can process nucleic acid inputs in a reusable format.