Inside Cover: Selective Protein Hyperpolarization in Cell Lysates Using Targeted Dynamic Nuclear Polarization (Angew. Chem. Int. Ed. 36/2016). Issue 36 (14th July 2016)

• Record Type: Journal Article
• Authors: Viennet, Thibault; Viegas, Aldino; Kuepper, Arne; Arens, Sabine; Gelev, Vladimir; Petrov, Ognyan; Grossmann, Tom N.; Heise, Henrike; Etzkorn, Manuel
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 36(2016)
• Page Start: 10526
• Page End: 10526
• Publication Date: 2016-07-14
• Subjects: cell lysates -- NMR spectroscopy -- proteins -- structure elucidation -- structural biology; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201606093
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Directing hyperpolarization to a target protein makes it possible to selectively filter out signals of specific proteins from a large background. In their Communication onpage 10746 ff., M. Etzkorn et al. show that dynamic nuclear polarization can be directed to a target protein by using a biradical‐labeled ligand. The resulting reduction of the background facilitates solid‐state NMR studies of the target protein in increasingly native environments.