Diverse N‐Heterocyclic Ring Systems via Aza‐Heck Cyclizations of N‐(Pentafluorobenzoyloxy)sulfonamides. Issue 37 (27th July 2016)

• Record Type: Journal Article
• Authors: Hazelden, Ian R.; Ma, Xiaofeng; Langer, Thomas; Bower, John F.
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 37(2016)
• Page Start: 11198
• Page End: 11202
• Publication Date: 2016-07-27
• Subjects: aza-Heck reaction -- cascade reactions -- N-heterocycles -- palladium; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201605152
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Aza‐Heck cyclizations initiated by oxidative addition of Pd 0 ‐catalysts into the N−O bond of N ‐(pentafluoro‐benzoyloxy)sulfonamides are described. These studies, which encompass only the second class of aza‐Heck reaction developed to date, provide direct access to diverse N ‐heterocyclic ring systems. Abstract : Aza‐Heck cyclizations initiated by oxidative addition of Pd 0 catalysts into the N−O bond of N ‐(pentafluorobenzoyloxy)sulfonamides are described. These studies, which are only the second class of aza‐Heck reaction developed to date, provide direct access to diverse N ‐heterocyclic ring systems (18 examples, 42–91 % yield).