Boronate Affinity–Molecularly Imprinted Biocompatible Probe: An Alternative for Specific Glucose Monitoring. Issue 16 (29th July 2016)

• Record Type: Journal Article
• Authors: Chen, Guosheng; Qiu, Junlang; Fang, Xu'an; Xu, Jianqiao; Cai, Siying; Chen, Qing; Liu, Yan; Zhu, Fang; Ouyang, Gangfeng
• Is Part Of: Chemistry, an Asian journal. Volume 11:Issue 16(2016)
• Page Start: 2240
• Page End: 2245
• Publication Date: 2016-07-29
• Subjects: biosensors -- boronate affinity -- glucose -- molecular imprinting -- self-assembly; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/asia.201600797
• Languages: English
• ISSNs: 1861-4728

Abstract

Abstract: A biocompatible probe for specific glucose recognition is based on photoinitiated boronate affinity–molecular imprinted polymers (BA‐MIPs). The unique pre‐self‐assembly between glucose and boronic acids creates glucose‐specific memory cavities in the BA‐MIPs coating. As a result, the binding constant toward glucose was enhanced by three orders of magnitude. The BA‐MIPs probe was applied to glucose determination in serum and urine and implanted into plant tissues for low‐destructive and long‐term in vivo continuous glucose monitoring. Abstract : Sticky sweet : A glucose probe based on photoinitiated boronate affinity–molecular imprinted polymers (BA‐MIPs) enhances the binding by three orders of magnitude owing to glucose memory cavities formed by pre‐self‐assembly. The selectivity of the BA‐MIPs probe was 85 % in the multi‐monosaccharide coexistent system, and the tolerance against amino acids, aliphatic acids, glycoprotein and other monosaccharide was superb.